Endocrine Abstracts

Background: According to the literature, glucocorticoid receptor (GR) function is modulated by phosphorylation. Retinoic acid (RA) can activate some cytoplasmic kinases able to phosphorylate GR.Aim: As RA and glucocorticoids interact in neuronal cells, we investigated whether RA could modulate GR phosphorylation in such cells.Methods: HT-22 hippocampal cells were cultured 4d with or without dexamethasone (Dex, 10-6 M) or RA (10-6 M...